Approaches to prenatal cystic fibrosis carrier screening.
نویسندگان
چکیده
منابع مشابه
Cystic fibrosis carrier screening.
Carrier screening for cystic fibrosis (CF) has been available since the early 1990s, yet there are few programs, and none funded as part of a national health care strategy. The aim of this paper is to provide a description of carrier screening for CF and examine the progress that has been made towards the establishment of universal population-based carrier screening programs. This is an evidenc...
متن کاملA cost-effectiveness analysis of prenatal carrier screening for cystic fibrosis.
OBJECTIVE To examine the cost-effectiveness of prenatal carrier screening for cystic fibrosis. METHODS A cost-benefit equation was developed that was based on the hypothesis that the cost of prenatal diagnosis required to diagnose and prevent one case of cystic fibrosis should be equal to or less than the lifetime cost generated from the birth of a neonate with cystic fibrosis. The formula wa...
متن کاملPrenatal maternal plasma DNA screening for cystic fibrosis: A
Prenatal cystic fibrosis (CF) screening is currently based on Background: determining the carrier status of both parents. We propose a new method based only on the analysis of DNA in maternal plasma. The method relies on the quantitative amplification of the CF gene to Methods: determine the percentage of DNA fragments in maternal plasma at targeted CF mutation sites that carry a CF mutation. C...
متن کاملPrenatal cystic fibrosis screening in Mexican Americans: an economic analysis.
OBJECTIVE We evaluated the cost benefit of cystic fibrosis screening in Mexican American gravid women. STUDY DESIGN With the use of decisions analysis techniques, a cost-benefit analysis was performed. Baseline assumptions were based on published references. Sensitivity analyses were performed. RESULTS Under the baseline assumptions, screening was not cost beneficial. Threshold analysis sho...
متن کاملImplications of carrier identification in newborn screening for cystic fibrosis.
OBJECTIVE To investigate the psychosocial implications for families whose infant was identified as a cystic fibrosis carrier by newborn screening. DESIGN Prospective psychosocial assessment. SETTING Primary care. RESPONDENTS STUDY (a) families of an affected infant identified by screening (n = 9); (b) families of a carrier infant identified by screening (n = 10). CONTROL group of mot...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1993
ISSN: 1468-6244
DOI: 10.1136/jmg.30.7.621-a